Experimental Pathology Core
The Experimental Pathology (ExPath) Core Laboratory provides investigators with centralized, comprehensive histological services. The core can process and section frozen and paraffin-embedded tissues. Slides can be prepared for staining, molecular studies, and laser capture
dissection. The core provides a variety of standard pathological stains for histochemical analysis of tissues, including hematoxylin and eosin, special stains, and immunohistochemistry. As needed, the laboratory works with investigators to develop immune-staining approaches for detecting specific targets of interest. The core is equipped with two Aperio slide scanners (bright-field and fluorescence) for capturing whole-slide images, which can be analyzed using Aperio ImageScope software with algorithms for color deconvolution, nuclear and membrane localization, and quantifying positive pixel number and intensity. Finally, clinical pathologists can assist with image analysis and data interpretation.